Next up for the 35-year-old will be another American in 39th-ranked Tommy Paul with a potential semi-final clash against top-seeded Russian Daniil Medvedev, who he defeated in the Australian Open final from a two-sets deficit.
Roger Federer's reign as world number one could end this week after he was beaten 7-6, 4-6, 7-6 by Croatian Ivo Karlovic in the third round of the Cincinnati Masters.
Roger Federer saw his men's record haul of 20 Grand Slam singles titles matched by Rafael Nadal on Sunday and the Swiss great was quick to offer his congratulations to the Spaniard.
Fifth seed Roger Federer was dumped out of the Shanghai Open, losing to Frenchman Gael Monfils 6-4, 6-7(5), 6-3 in the third round on Thursday.
Top seeds Sania and her Brazilian partner Bruno Soares edged past Abigail Spears and Santiago Gonzalez.
For good reason a two-week Grand Slam can be described as a 'last man standing' marathon of mental and physical endurance, which makes Roger Federer's haul of 19 all the more incredible.
Leander Paes and Martina Hingis won their mixed doubles opener at the Australian Open tennis tournament on Sunday.
Serena Williams moved another step closer to a record-tying 24th career Grand Slam title with a comfortable 6-3, 6-2 victory over Czech Karolina Muchova on Friday to reach the last 16 at the US Open.
India's top singles player Somdev Devvarman was on Saturday drawn to a play a qualifier while wild cards Yuki Bhambri and Jeeven Nedunchehziyan will have to fight it out with top-100 players in their first rounds at the Aircel Chennai Open.
Four-time Wimbledon semi-finalist Tim Henman of Great Britain has his money on Novak Djokovic as the favourite to win the Australian Open while Roger Federer's best chance to add to his kitty of 17 Grand Slams is at the Wimbledon, this year.
India's Sania Mirza and her Swiss partner Martina Hingis stormed into the US Open women's doubles final following a 6-4, 6-1 win over 11th seeded Italians Sara Errani and Flavia Pennetta in New York, on Wednesday night.
Summary of sports events and persons who made news on Tuesday
Nadal paid tribute to his uncle and coach Toni after winning a record-extending 10th French Open title on Sunday.
World number one and top seed Rafa Nadal will launch his U.S. Open campaign against Russia's Teymuraz Gabashvili after the singles draw for the last grand slam of the year was made at Flushing Meadows on Thursday.
Tennis legend Bjorn Borg is tipping Britain's No 1 tennis player Andy Murray to win his first Grand Slam at the US Open next week and rates him as competitive as Swiss star Roger Federer and Wimbledon's 2008 champion Rafael Nadal.
Factbox on Switzerland's Roger Federer, who defeated Rafael Nadal in the Australian Open men's singles final on Sunday.
Serena Williams' bid for the Italian Open was squashed in her first match on Tuesday when the American second seed lost 6-2, 2-6, 6-1 to Swiss Patty Schnyder. French Open champion Ana Ivanovic beat Italian Francesca Schiavone 6-3, 6-4 and seventh seed Svetlana Kuznetsova of Russia had a comfortable 6-3, 6-3 win over Slovak Daniela Hantuchova.
Novak Djokovic and Roger Federer remain on course for a marquee one-two clash in the men's US Open final, but each must first vanquish a formidable opponent and friend in Friday's semi-finals at Flushing Meadows.
Roger Federer made a winning return to the grass courts
Novak Djokovic summoned some cinematic inspiration to help him conquer grand slam king Roger Federer and silence the roaring supporters of the Swiss at Sunday's US Open men's final.
Federer showed that he is prepared to take as many knocks as it takes to keep alive his dreams
Photos from the French Open matches played at the Roland Garros on Thursday
The Santina juggernaut rolls as the Indo-Swiss pair of Sania Mirza and Martina Hingis overcame the Czech duo Andrea Hlav?kov and Lucie Hradeck in straight sets to win the Australian Open at the Rod Laver Arena on Friday. The World No.1 duo defeated their seventh seed opponents 7-6, 6-3 in under two hours to clinch their third title in Australia after winning in Brisbane and Sydney earlier this year. This was their third major (2015 Wimbledon and U.S Open) and twelfth doubles title together as Sania and Martina extended their winning streak to 36 matches. Images from Santina's title victory in Melbourne.
Roger Federer will begin his quest for a sixth consecutive singles title at Wimbledon with a first round match against experienced Slovak Dominik Hrbaty. Defending women's champion Venus Williams was paired with British wildcard Naomi Cavaday in Friday's draw at the All England Club, while women's top seed Ana Ivanovic will open against Rossana De Los Rios.
The win put Nadal one clear of Federer and world number one Djokovic on the all-time Grand Slam titles race.
Federer may have set the benchmark on how to do tennis retirements. He didn't go out in a blaze of lonely glory but in the warmth of friendships formed over the years, observes Deepti Patwardhan.
PV Sindhu cruised into the second round but compatriot Saina Nehwal bowed out fighting in the Badminton Asia Championships.
Roger Federer and Mareia Sharapova provided proved too strong in gale-force winds to breeze into the fourth round of the US Open on Saturday.
Five-times defending champion Roger Federer and Russian Dinara Safina will be the top seeds at the U.S. Open when it begins next Monday, the U.S. Tennis Association said on Tuesday.
Ace Indian shuttler Saina Nehwal advanced to the quarter-finals of the Indonesia Super Series Premier tournament with a comfortable straight-game win over local favourite Fitriani Fitriani in the women's singles event in Jakarta on Thursday.
The Indian challenge in the doubles event of the ATP Chennai Open ended on Friday when top seeds Mahesh Bhupathi and partner Mark Knowles of Bahamas were shocked by the unseeded Swiss duo of Jean Claude Scherrer and Stanislas Wawrinka 3-6, 6-3, 8-10 in the quarter-finals.
Belgium's Elise Mertens rallied from a set down to beat top seed Simona Halep 3-6, 6-4, 6-3 and clinch her first Premier-level title at the Qatar Open on Saturday.
Tennis is like "riding a bike" for Federer, who is not worried about his game or starting with "really low" expectations, but is more interested to see how his knee reacts to the rigours of competitive tennis.
Australian Nick Kyrgios let his tennis do the talking against Stanislas Wawrinka as he knocked the fourth seed out of the Madrid Open with a scintillating display on Wednesday.
The world No 1 blasted past Germany's Benjamin Becker while the former British No 1 beat South Korea's Lee Hyung-taik in the semi-finals.
World No 1 Djokovic on Sunday won his sixth Wimbledon title. With this win, Djokovic now has 20 Grand Slams to his name and he is now equal with Swiss tennis maestro Roger Federer and Nadal.
Roger Federer is poised to write more tennis history at the U.S. Open this weekend against semi-final opponent Nikolay Davydenko at the National Tennis Center.
All of a sudden, talk of Roger Federer's supposed decline has disappeared and he is looming as the form player heading into the U.S. Open brimful of confidence.